Intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes.
نویسندگان
چکیده
The intracellular penetration and activity of gemifloxacin in human polymorphonuclear leukocytes (PMN) were evaluated. Gemifloxacin reached intracellular concentrations eight times higher than extracellular concentrations. The uptake was rapid, reversible, and nonsaturable and was affected by environmental temperature, cell viability, and membrane stimuli. At therapeutic extracellular concentrations, gemifloxacin showed intracellular activity against Staphylococcus aureus.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 44 11 شماره
صفحات -
تاریخ انتشار 2000